Lys & Arg have four ionisations zones

1. 1--------pK1 – charge +2

2. pK1---------pK2 charge +1

3. pK2---------pKr charge 0

4. pKr---------14 charge -1

TLS Online TPP Program

#Id: 1348

#XL - T Zoology

RasD or RasONC  Replacement of the normal glycine 12 with any other amino acid (except proline) “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 1349

#XL - T Zoology

RAF (also known as MAPKKK),  A ser/thr protein kinase

TLS Online TPP Program

#Id: 1350

#XL - T Zoology

KSR (Kinase suppressor of Ras) is a pseudogene homolog of RAF Involve in the activation of RAF

TLS Online TPP Program

#Id: 1351

#XL - T Zoology

CNK serves as a molecular scaffold platform for KSR-mediated RAF activation

 

TLS Online TPP Program

#Id: 1352

#XL - T Zoology

GRB2 SH3 domains bind to proline-rich sequences in Sos

  

TLS Online TPP Program

#Id: 1353

#XL - T Zoology

GRB2 SH2 domain binds to a specific phosphotyrosine residue in the cytosolic domain of an activated RTK.