Elongation phase

short oligomer rapidly increases in length by the addition of actin monomers to both of its ends, causing filament elongation

TLS Online TPP Program

#Id: 10030

#XL - T Zoology

A single molecule of I-κBα binds to N-terminal domains of the p50–p65 subunits, masking their NLS.

TLS Online TPP Program

#Id: 10031

#XL - T Zoology

I-κB kinase 

three-protein complex and is responsible for releasing NF-κB from sequestration

TLS Online TPP Program

#Id: 10032

#XL - T Zoology

Within minutes of stimulation of the cell, β subunit of

I-κB kinase becomes activated by phosphorylation

TLS Online TPP Program

#Id: 10033

#XL - T Zoology

β subunit of I-κB kinase phosphorylates two N-terminal serine residues on I-κBα

TLS Online TPP Program

#Id: 10034

#XL - T Zoology

An E3 ubiquitin ligase binds to Phosphoserines of I-κBα & links poly-K48-linked ubiquitin chains that target the attached I-κBα protein to the proteasomal degradation

TLS Online TPP Program

#Id: 10035

#XL - T Zoology

NF-κB signaling is turned off by negative feedback

regulation because one of the genes whose transcription is induced by NF-κB encodes I-κBα.