Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

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#Id: 7883

#XL - Q Biochemistry

MICOS function as a diffusion barrier to prevent mixing of the distinct proteins and lipids in the boundary membrane and crista membranes.

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#Id: 7884

#XL - Q Biochemistry

The most abundant protein in the outer mitochondrial membrane is a mitochondrial β-barrel porin called VDAC (voltage-dependent anion channel).

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#Id: 7885

#XL - Q Biochemistry

VDAC 

A multifunctional transmembrane channel protein (similar in structure to bacterial porins) allow passing of  ions and most small hydrophilic molecules (up to about 5000 Da).

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#Id: 7886

#XL - Q Biochemistry

Mitochondria are associated with the cytoskeleton, which determines their distribution in different cell types.

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#Id: 7887

#XL - Q Biochemistry

In highly polarized cells, mitochondria can move long distances being propelled along microtubule tracks

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#Id: 7888

#XL - Q Biochemistry

In other cells, mitochondria remain fixed at points of high energy demand.