Hexokinase IV is not inhibited by glucose 6-phosphate, and it can therefore continue to operate 

when the accumulation of glucose 6-phosphate completely inhibits hexokinases I–III. 

TLS Online TPP Program

#Id: 9367

#XL - T Zoology

BMP proteins, activate a different set of receptors that are similar to the TGF-β RI and RII proteins but phosphorylate other R-Smads, Smad1, Smad5, & Smad8

TLS Online TPP Program

#Id: 9368

#XL - T Zoology

Smad4 was originally called DPC (deleted in pancreatic cancer)

TLS Online TPP Program

#Id: 9369

#XL - T Zoology

Negative regulators of TGF-β signaling are induced by TGF-β signaling (Example of Negative feedback): 

Ski 

SnoN 

I-Smads (Smad7)

TLS Online TPP Program

#Id: 9370

#XL - T Zoology

SnoN and Ski trigger abnormal cell proliferation by blocking the Smad-complex.

TLS Online TPP Program

#Id: 9371

#XL - T Zoology

TLS Online TPP Program

#Id: 9372

#XL - T Zoology

Ski recruits N-CoR, which binds directly to mSin3A; mSin3A interacts with HDAC, that promotes histone deacetylation on nearby promoters, repressing gene expression