Chk1, Chk2, and MK2

cause cell cycle arrest by inhibiting Cdc25

stabilizing the transcription factor p53, which induces the transcription of CKI p21 

TLS Online TPP Program

#Id: 8892

#XL - T Zoology

Amphitelic attachment, 

sister kinetochores attach to microtubules emanating from opposite spindle poles, they are stably attached

TLS Online TPP Program

#Id: 8893

#XL - T Zoology

Merotelic attachment 

A kinetochore can attach to microtubules emanating from both poles at the same time

TLS Online TPP Program

#Id: 8894

#XL - T Zoology

Syntelic attachment 

Both kinetochores of a sister chromatid pair can attach to microtubules from the same pole

TLS Online TPP Program

#Id: 8895

#XL - T Zoology

Monotelic attachment 

only one kinetochore can attach to microtubules

TLS Online TPP Program

#Id: 8897

#XL - T Zoology

Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

TLS Online TPP Program

#Id: 8898

#XL - T Zoology

If Amphitelic attachment occur  Microtubules pull kinetochores; cohesins resist this pulling force. The resulting tension leads to the outer kinetochore component Ndc80 being pulled away from the protein kinase Aurora B