TLS Online TPP Program

#Id: 8205

#XL - Q Biochemistry

Membranes of late endosomes and lysosomes contain V-class proton pumps that act in concert with Cl- channels to acidify the vesicle lumen.

TLS Online TPP Program

#Id: 8204

#XL - Q Biochemistry

Lysosome H+ pump are V-type ATPases and has a similar architecture to the F-type ATPases

TLS Online TPP Program

#Id: 8203

#XL - Q Biochemistry

An H+ ATPase in the membrane pumps H+ into the lysosome, maintaining its lumen at an acidic pH.

TLS Online TPP Program

#Id: 8202

#XL - Q Biochemistry

Most of the lysosome membrane proteins, are highly glycosylated, which helps to protect them from the lysosome proteases

TLS Online TPP Program

#Id: 8201

#XL - Q Biochemistry

Lysosome an interior pH of about 4.5–5.0

TLS Online TPP Program

#Id: 8199

#XL - Q Biochemistry

Lysosomes contain about 40 types of hydrolytic enzymes, All are acid hydrolases, work best at acidic pH including: proteases, nucleases, glycosidases, lipases, phospholipases, phosphatases, and sulfatases.