In response to elevated cytosolic Ca²+ 

PKC is recruited to the plasma membrane, where it is activated by DAG

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Intracellular infections are the most difficult for the immune system to detect and eradicate; these can be divided into membrane-bound and cytosolic, with differing key immune response mediators

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Viral Infections

Virus enters a cell via a cell-surface receptor for which it has affinity and preempts cell biosynthetic machinery to replicate all components of itself, including its genome.

This genome replication step is often error prone, generating numerous mutations.

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Influenza virus binds to sialic acid residues

Rhinovirus binds to intercellular adhesion molecules (ICAMs)

Epstein Barr virus (EBV) binds to type 2 complement receptors on B cells

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Innate response elements commonly engaged by encounter with viral PAMPs, such as secretion of type I interferons, inflammasome and NK-cell activation, as well as IL-12 production.

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Mechanisms of humoral and cell-mediated immune responses

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Many Viruses Are Neutralized by Antibodies

Antibodies are particularly effective if they are localized at the site of viral entry into the body.