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TLS Online TPP Program

#Id: 9159


#XL - T Zoology #Factor affecting Hardy Weinberg equilibrium #Part B Pointers
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TLS Online TPP Program

#Id: 9348

#XL - T Zoology

3 separate TGF-β receptor proteins participate in binding TGF-β and activating signaling:
RI, RII, and RIII

TLS Online TPP Program

#Id: 9350

#XL - T Zoology

RI and RII receptors are homodimeric proteins with serine/threonine kinases in their cytosolic domains. 
(RI and RII sufficient to serve as a functional hetero-tetrameric TGF-β receptor)

TLS Online TPP Program

#Id: 9351

#XL - T Zoology

RII exhibits constitutive kinase activity; means it is active even when not bound to TGF-β.

TLS Online TPP Program

#Id: 9352

#XL - T Zoology

RIII, also called β-glycan, is a cell-surface proteoglycan.

TLS Online TPP Program

#Id: 9353

#XL - T Zoology

The function of RIII for TGF-β receptors is similar to that of the α subunit of the IL-2 receptor 
(means facilitating TGF-β binding to the RII and RI)

   
         

TLS Online TPP Program

#Id: 9355

#XL - T Zoology

Most cells lack RIII, TGF-β binds directly to the RII
dimer, but Active RII kinase activity is not sufficient to generate an intracellular signal

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