Genetic drift 

Genetic drift is an evolutionary force, in which allelic frequency change over generation Just by chance (sampling error). 

The deviations from the expected ratios are random, the direction of change is unpredictable.

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Kinesin-1 

is regulated by a 

head-to-tail interaction

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Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

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Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

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Troponin C is closely related to the ubiquitous 

Ca2+-binding protein calmodulin