RI and RII receptors are homodimeric proteins with serine/threonine kinases in their cytosolic domains. 

(RI and RII sufficient to serve as a functional hetero-tetrameric TGF-β receptor)

TLS Online TPP Program

#Id: 8910

#XL - T Zoology

Before anaphase Separase is inhibited by the binding of the protein securin and Mitotic CDKs.

TLS Online TPP Program

#Id: 8911

#XL - T Zoology

TLS Online TPP Program

#Id: 8912

#XL - T Zoology

When all the kinetochores have properly attached to spindle microtubules, APC/CCdc20 directs ubiquitinylation of securin and mitotic cyclins

TLS Online TPP Program

#Id: 8913

#XL - T Zoology

APC/CCdc²⁰ is inhibited by a checkpoint pathway that ensures that anaphase is not initiated until all chromosomes have achieved proper attachment to the mitotic apparatus.

TLS Online TPP Program

#Id: 8914

#XL - T Zoology

Following securin degradation and a decrease in mitotic CDK activity, separase cleaves the Scc1 subunit, breaking the cohesin circles.

TLS Online TPP Program

#Id: 8915

#XL - T Zoology

Mitotic exit network plays an important role in shutting off mitotic cyclins by controlling the activation of the Cdc14 phosphatase through a GTPase pathway.