RII phosphorylates serine and threonine in the juxtamembrane segment of the RI (ligand induced receptor hetero-oligomerization), releasing the inhibition of RI kinase activity.

TLS Online TPP Program

#Id: 10012

#XL - T Zoology

Ptc contains 12 TM α helices and structurally similar

to the Niemann-Pick C1 protein, a cholesterol transporting member of the ABC superfamily

TLS Online TPP Program

#Id: 10013

#XL - T Zoology

In the absence of Hh,

Ptc inhibits Smoothened and then degraded in proteasomes

TLS Online TPP Program

#Id: 10014

#XL - T Zoology

Transcription Factor

zinc-finger transcription factor Cubitis interruptus

TLS Online TPP Program

#Id: 10015

#XL - T Zoology

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 10016

#XL - T Zoology

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).

TLS Online TPP Program

#Id: 10017

#XL - T Zoology

In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.