Phosphorylated STAT dissociates spontaneously from the receptor, and two phosphorylated STAT proteins form a homodimer.

TLS Online TPP Program

#Id: 8626

#XL - T Zoology

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#XL - T Zoology

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#XL - T Zoology

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#XL - T Zoology

APC/C works with substrate-targeting factors called Cdc20 and Cdh1

TLS Online TPP Program

#Id: 8630

#XL - T Zoology

TLS Online TPP Program

#Id: 8631

#XL - T Zoology

APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module