In the most famous example of Lamarck’s theory, giraffes must have stretched their necks to reach foliage above them, and so their necks were lengthened

The longer necks were inherited, and over the course of generations, this process was repeated, and their necks got longer and longer. 

TLS Online TPP Program

#Id: 9689

#XL - T Zoology

Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

#Id: 9690

#XL - T Zoology

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.

TLS Online TPP Program

#Id: 9691

#XL - T Zoology

Movement of the GSVs to the plasma membrane is regulated by two monomeric GTP-binding proteins -RalA and Rab10

TLS Online TPP Program

#Id: 9692

#XL - T Zoology

Insulin receptor activates the PI-3 kinase/PKB pathway

TLS Online TPP Program

#Id: 9693

#XL - T Zoology

Active PKB, phosphorylates

and inhibits the GTP→GDP hydrolysis activity of two GAP

proteins - AS160 and RGC

TLS Online TPP Program

#Id: 9694

#XL - T Zoology

Phosphorylation causes the binding of AS160 to the 

14-3-3 protein that sequesters it in the cytosol away from its target Rab proteins