Ronald A. Fisher, John B. S. Haldane and Sewall Wright - which showed that mutation and natural selection together cause adaptive evolution.

TLS Online TPP Program

#Id: 9479

#XL - T Zoology

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 9481

#XL - T Zoology

TLS Online TPP Program

#Id: 9608

#XL - T Zoology

For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)

TLS Online TPP Program

#Id: 9609

#XL - T Zoology

Phosphorylation leads to a conformational change in the activation loop that unblocks kinase active site by reducing the Kd for ATP or the substrate to be phosphorylated.

TLS Online TPP Program

#Id: 9610

#XL - T Zoology

Insulin receptor, form disulfide-linked dimers in the absence of hormone.

TLS Online TPP Program

#Id: 9611

#XL - T Zoology

Binding of ligand to predimerized but inactive RTK alters the conformation of the dimer in such a way that the receptor’s kinase becomes activated.