Upon insulin binding, the extracellular domain is converted into a T-shaped conformation that brings the transmembrane domains together.

TLS Online TPP Program

#Id: 10070

#XL - T Zoology

Three classes of classical cadherins: 

E-cadherin -present on epithelial cells

N-cadherin - present on nerve, muscle and lens cells

P-cadherin - present on cells in the placenta & epidermis

TLS Online TPP Program

#Id: 10071

#XL - T Zoology

Nonclassical cadherins include proteins:

Protocadherins found in the brain

Desmocollins and desmogleins that form desmosomes

TLS Online TPP Program

#Id: 10072

#XL - T Zoology

Epithelial-to-mesenchymal transition is associated with a reduction in the expression of E-cadherin.

TLS Online TPP Program

#Id: 10073

#XL - T Zoology

Snail suppresses the expression of E-cadherin is associated with the EMT

TLS Online TPP Program

#Id: 10074

#XL - T Zoology

A cadherin-family member CDHR3, highly expressed in epithelial cells in the human airway, as a receptor for RV-C (virulent class C rhinoviruses).

TLS Online TPP Program

#Id: 10075

#XL - T Zoology

In cultured cells, C → Y mutation in the EC5 domain of CDHR3 increases the cell-surface expression of CDHR3 and the binding and replication of RV-C.