Upon insulin binding, the extracellular domain is converted into a T-shaped conformation that brings the transmembrane domains together.

TLS Online TPP Program

#Id: 8175

#XL - Q Biochemistry

SNARE-mediated fusion occurs during exocytosis of secreted proteins. In this case, 

v-SNARE, are VAMP 

t-SNAREs are syntaxin & SNAP-25

TLS Online TPP Program

#Id: 8174

#XL - Q Biochemistry

Sets of SNARE Proteins responsible for the eventual fusion of a vesicle with the target membrane:

Vesicle-specific membrane protein, v-SNARE

Target membrane contains t-SNARE

TLS Online TPP Program

#Id: 8173

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8172

#XL - Q Biochemistry

Effector proteins of Rab6 is Kinesin

Effector proteins of Rab27 is Type V Myosin

TLS Online TPP Program

#Id: 8171

#XL - Q Biochemistry

In mammalian cells, Rab5 protein (early endosomes) and its effector protein known as EEA1 (early endosome antigen 1)

TLS Online TPP Program

#Id: 8170

#XL - Q Biochemistry

In yeast Rab protein is the Sec4 and its effectors are exocyst and Type V Myosin.