Upon insulin binding, the extracellular domain is converted into a T-shaped conformation that brings the transmembrane domains together.

TLS Online TPP Program

#Id: 1338

#XL - T Zoology

The EGFR specifically binds EGF in a lock-and-key type of mechanism.

TLS Online TPP Program

#Id: 1339

#XL - T Zoology

The function of a growth factor-  stabilize receptor dimerization

TLS Online TPP Program

#Id: 1340

#XL - T Zoology

HER1 & HER4, can form stable homodimers after binding a growth factor.

TLS Online TPP Program

#Id: 1341

#XL - T Zoology

HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

TLS Online TPP Program

#Id: 1342

#XL - T Zoology

HER3 lacks a functional kinase domain

TLS Online TPP Program

#Id: 1343

#XL - T Zoology

RAS is a small monomeric G-proteins.