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Constitutively active Ras proteins (RasD) 
Replacement of the normal glycine 12 with any other amino acid (except proline) blocks the functional binding of GAP proteins and in essence “locks” Ras in the active GTP-bound state.

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Insulin activates
GluT4
Hexokinase
Glycogen Synthase

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The predominant hexokinase isozyme of liver is hexokinase IV (glucokinase) and it is GLUT2 dependent

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Hexokinase IV is not inhibited by glucose 6-phosphate, and it can therefore continue to operate 
when the accumulation of glucose 6-phosphate completely inhibits hexokinases I–III. 

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