Constitutively active Ras proteins (RasD) 

Replacement of the normal glycine 12 with any other amino acid (except proline) blocks the functional binding of GAP proteins and in essence “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 8391

#XL - Q Biochemistry

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 8373

#XL - Q Biochemistry

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.

TLS Online TPP Program

#Id: 8372

#XL - Q Biochemistry

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8371

#XL - Q Biochemistry

In the presence of ATP,  myosin head releases from the actin filament. 

TLS Online TPP Program

#Id: 8370

#XL - Q Biochemistry

In the absence of ATP, the myosin head is firmly attached to the actin filament. 

TLS Online TPP Program

#Id: 8369

#XL - Q Biochemistry

The length of the myosin II neck domain determines the rate of movement.