Phosphorylation by MEK at Y-185 and T-183 in activation loop of MAP kinase leads to a marked conformational change & promotes MAP kinase activation and dimerization.

TLS Online TPP Program

#Id: 9905

#XL - T Zoology

TLS Online TPP Program

#Id: 8096

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 10091

#XL - T Zoology

Outside-in signaling

Binding of integrins to their ligands induces conformational changes in their cytoplasmic domains, directly or indirectly altering their interactions with cytoplasmic proteins

TLS Online TPP Program

#Id: 8127

#XL - T Zoology

β-Carotene is the precursor of vitamin A1.
Oxidation at C-15 converts retinol to the aldehyde, retinal, and further oxidation produces retinoic acid, a hormone that regulates gene expression. 

TLS Online TPP Program

#Id: 10806

#XL - R Botany

Nitrogen - containing compounds