Main action of the PKB signaling pathway

An increase in uptake of glucose from the blood within minutes.

TLS Online TPP Program

#Id: 10062

#XL - T Zoology

In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

#XL - T Zoology

CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins

TLS Online TPP Program

#Id: 10064

#XL - T Zoology

The adhesiveness of cadherins depends on the presence of extracellular Ca2+

TLS Online TPP Program

#Id: 10065

#XL - T Zoology

Two type of Cadherins:

1. Classical cadherin proteins

2. Nonclassical cadherin proteins

TLS Online TPP Program

#Id: 10066

#XL - T Zoology

Extracellular region of a classical cadherin contains five copies of the cadherin domain separated by flexible hinge regions

TLS Online TPP Program

#Id: 10067

#XL - T Zoology

Ca2+ ions bind to sites near each hinge and prevent it

from flexing, so that the whole string of cadherin domains behaves as a rigid and slightly curved rod to generate cell–cell adhesion