The NBS–LRR receptor remains inactive when bound to the guardee. However, when the effector interacts with the guardee, the NBS– LRR receptor becomes activated, triggering a signaling cascade that leads to the defense response.

TLS Online TPP Program

#Id: 10011

#XL - T Zoology

Smo has seven TM α helices, is a member of the GPCR superfamily, and is related in sequence to the Fz.

TLS Online TPP Program

#Id: 9985

#XL - T Zoology

Antagonists of Wnt:

Secreted frizzled-related protein (Sfrp)

Wnt inhibitory factor (Wif)

Dickkopf (Dkk) family

TLS Online TPP Program

#Id: 10291

#XL - Q Biochemistry

The second phase of T-cell development

1.Positive selection: Selection for those cells whose T-cell receptors engage self-MHC.

2.Negative selection: Selection against those cells whose T-cell receptors bind too strongly to self-peptide/MHC combinations.

3.Lineage commitment: Commitment of thymocytes to effector cell lineages, including CD4 helper or CD8 cytotoxic populations

TLS Online TPP Program

#Id: 10071

#XL - T Zoology

Nonclassical cadherins include proteins:

Protocadherins found in the brain

Desmocollins and desmogleins that form desmosomes

TLS Online TPP Program

#Id: 9968

#XL - T Zoology

“canonical” Wnt signaling uses a second TM protein, LRP that associates with Frizzled in a Wnt signal– dependent manner.