Inflammasomes

Multiprotein complex that promotes inflammation by processing inactive precursor forms of pro-inflammatory cytokines such as IL-1 and IL-18.

Proinflammatory cytokines IL-1β, TNF, and IL-6. 

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Phosphorylation of PKA at threonine-197 leads to conformational change in the activation loop, that promotes binding of both ATP and its substrate proteins.

PKA can autophosphorylate itself on T197

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The activities of GPK and GP are inhibited by a phosphatase called phosphoprotein phosphatase.

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The promoter or enhancer segments of all genes regulated by PKA contain a cis-acting DNA sequence, the cAMP-response element (CRE), which

contains the highly conserved nucleotide sequence,

5'-TGACGTCA-3'.

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In nucleus PKA phosphorylate serine-133 on a transcription factor called CREbinding (CREB) protein

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Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription

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