Intracellular infections are the most difficult for the immune system to detect and eradicate; these can be divided into membrane-bound and cytosolic, with differing key immune response mediators

TLS Online TPP Program

#Id: 8147

#XL - Q Biochemistry

A clathrin molecule,

called a triskelion, is composed of : 

Three heavy chains

Three light chains

TLS Online TPP Program

#Id: 8148

#XL - Q Biochemistry

Depolymerization of the clathrin coat into triskelions  by Cytosolic Hsp70

TLS Online TPP Program

#Id: 8149

#XL - Q Biochemistry

ARF and Sar1 similar to Ras

TLS Online TPP Program

#Id: 8150

#XL - Q Biochemistry

Sar1 is the only GTPase switch protein activated at the ER membrane

TLS Online TPP Program

#Id: 8151

#XL - Q Biochemistry

Sec12

acts as a GEF factor for Sar1

TLS Online TPP Program

#Id: 8152

#XL - Q Biochemistry

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.