Viral Infections

Virus enters a cell via a cell-surface receptor for which it has affinity and preempts cell biosynthetic machinery to replicate all components of itself, including its genome.

This genome replication step is often error prone, generating numerous mutations.

TLS Online TPP Program

#Id: 9685

#XL - T Zoology

Main action of the PKB signaling pathway

An increase in uptake of glucose from the blood within minutes.

TLS Online TPP Program

#Id: 9686

#XL - T Zoology

Fat and muscle cells express large amounts of the insulin-responsive glucose transporter GLUT4

TLS Online TPP Program

#Id: 9687

#XL - T Zoology

In resting cells, the majority of the GLUT4 protein is

localized to specialized GLUT4 storage vesicles (GSVs)

TLS Online TPP Program

#Id: 9688

#XL - T Zoology

GSVs tethered to the Golgi matrix, by a protein termed TUG (Tether containing a UBX domain for GLUT4).

TLS Online TPP Program

#Id: 9689

#XL - T Zoology

Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

#Id: 9690

#XL - T Zoology

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.