Intracellular bacterial

Intracellular bacterial infections tend to induce a cell-mediated immune response, specifically DTH. 

In this response, cytokines secreted by CD4+ T cells are important—most notably IFN-ϒ, which activates macrophages.

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I-κB kinase 

three-protein complex and is responsible for releasing NF-κB from sequestration

TLS Online TPP Program

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Within minutes of stimulation of the cell, β subunit of

I-κB kinase becomes activated by phosphorylation

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#Id: 10033

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β subunit of I-κB kinase phosphorylates two N-terminal serine residues on I-κBα

TLS Online TPP Program

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An E3 ubiquitin ligase binds to Phosphoserines of I-κBα & links poly-K48-linked ubiquitin chains that target the attached I-κBα protein to the proteasomal degradation

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#Id: 10035

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NF-κB signaling is turned off by negative feedback

regulation because one of the genes whose transcription is induced by NF-κB encodes I-κBα.

TLS Online TPP Program

#Id: 10036

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Signalsomes 

Signal transduction by the interleukin 1 and TLRs involves formation of huge multiprotein complexes, activate I-κB kinase