Leishmaniasis

Leishmania is a flagellated protozoan that lives in the phagosomes of macrophages and is transmitted by sand flies.

TLS Online TPP Program

#Id: 8358

#XL - Q Biochemistry

On Endosomes 

Arp2/3-dependent nucleation of actin filament by An NPF is WASH

TLS Online TPP Program

#Id: 8357

#XL - Q Biochemistry

VASP 

has a proline-rich

hold onto the end of the newly formed filament

protect the end of the growing filament from CapZ

TLS Online TPP Program

#Id: 8356

#XL - Q Biochemistry

ActA protein binds the host protein VASP, which enhance actin assembly and confine it to the rear of the bacterium.

TLS Online TPP Program

#Id: 8354

#XL - Q Biochemistry

Listeria is a food-borne bacterial pathogen has on its surface a protein ActA, which mimics an NPF that efficiently activates the Arp2/3 complex.

TLS Online TPP Program

#Id: 8353

#XL - Q Biochemistry

A second NPF is a large protein complex called WAVE

and requires small GTP-binding protein Rac1.

TLS Online TPP Program

#Id: 8351

#XL - Q Biochemistry

WASp activation requires two signals (This type of two-signal input, called coincidence detection):

1. regulatory phospholipid PIP2

2. small GTP-binding protein Cdc42