Leishmaniasis

Leishmania is a flagellated protozoan that lives in the phagosomes of macrophages and is transmitted by sand flies.

TLS Online TPP Program

#Id: 7905

#XL - Q Biochemistry

Mitophagy provides Mitochondrial Quality Control

TLS Online TPP Program

#Id: 7904

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 7903

#XL - Q Biochemistry

Mitochondrial fusion and fission are mediated by a set of GTPase enzymes:

Mitochondrial fusion -MFN1/2 & OPA1

Mitochondrial fission- DRP1

TLS Online TPP Program

#Id: 7902

#XL - Q Biochemistry

Single mutation in the TΨCG loop of the mitochondrial lysine tRNA

“Ragged-red” muscle fibers & uncontrolled jerky movements

TLS Online TPP Program

#Id: 7901

#XL - Q Biochemistry

Deletions in mtDNA cause another set of diseases:

Chronic progressive external ophthalmoplegia

Kearns–Sayre syndrome

TLS Online TPP Program

#Id: 7900

#XL - Q Biochemistry

Leber’s hereditary optic neuropathy

caused by a missense mutation in the mtDNA gene

encoding subunit 4 of the NADH-CoQ reductase