β-catenin Destruction Complex contains:

Tumor suppressor APC

Dvl protein

Constitutively active protein kinases GSK 3β and CK1

TLS Online TPP Program

#Id: 8765

#XL - T Zoology

Disulfide bonds are believed to increase the stability of the native state by decreasing the conformational entropy of the unfolded state due to the conformational constraints imposed by cross-linking (i. e. decreasing the free energy of the unfolded state).  

TLS Online TPP Program

#Id: 8766

#XL - T Zoology

Most protein have "loops" introduced by disulfides of about 15 residues

TLS Online TPP Program

#Id: 8767

#XL - T Zoology

Guanidinium ion and urea are chaotropic agents which disrupts hydrophobic core of proteins.

TLS Online TPP Program

#Id: 8768

#XL - T Zoology

TLS Online TPP Program

#Id: 8769

#XL - T Zoology

TLS Online TPP Program

#Id: 8770

#XL - T Zoology