TLS Online TPP Program

#Question id: 815


The cis conformation shows Cα atoms are on the same side of the peptide bond, is ∼8 kJ mol−1 less stable than the trans conformation. Why?

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. steric interference between ketone and amide group

  2. because of steric interference between neighboring side chains

  3. conformational entropy will be high in cis conformation

  4. because the peptide bond is less stable