#Question id: 889
#Unit 1. Molecules and their Interaction Relevant to Biology
The cis and trans GroEL rings undergo conformational changes in a reciprocating fashion, with events in one ring influencing events in the other ring. The entire GroEL/ES chaperonin complex functions as follows;
a) One GroEL ring that has bound 7 ATP also binds an improperly folded substrate protein, which associates with hydrophobic patches that line the inner wall of the GroEL chamber
b) The GroES cap then binds to the GroEL ring like a lid on a pot, inducing a conformational change in the resulting cis ring
c) Within ~10 s the cis ring catalyzes the hydrolysis of its 7 bound ATPs and releases the resulting Pi , which weakens the interactions binding GroES to GroEL
d) A second molecule of improperly folded substrate protein binds to the cis ring, followed by 7 ATP
e) The binding of substrate protein and ATP to the cis ring conformationally induces the trans ring to release its bound GroES, 7 ADP, and the presumably now better-folded substrate protein
Which of the following is incorrect functions of GroEL/ES chaperonin complex?
#Question id: 10719
#Unit 10. Ecological Principles
#Question id: 6950
#Unit 5. Developmental Biology
In mammalian development, the embryo will form from which population of cells?
#Question id: 1535
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to cancer stem cell (CSCs).
a. A representative subpopulation of cancer cells with peculiar molecular aspects that resemble some of those typical of normal stem cells.
b. These cells are capable of replenishing the repertoire of identical cancer cells.
c. These cells cannot create heterogeneous progeny that differentiate into more mature cells.
d. These cells show extraordinary proliferative potential.
e. These cells show excessive programmed cell death.
Which of the following combination is correct?
#Question id: 12604
#Unit 10. Ecological Principles