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TLS Online TPP Program

#Question id: 4360

Which of the following functions are characteristic of general transcription factors in eukaryotes?

#Unit 3. Fundamental Processes

  1. They bind to other proteins or to the TATA box.

  2. They inhibit RNA polymerase binding to the promoter and begin transcribing.

  3. They usually lead to a high level of transcription even without additional specific transcription factors.

  4. They bind to sequences just after the start site of transcription.

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TLS Online TPP Program

#Question id: 12385

#Unit 7. System Physiology – Animal

To evaluate kidney function in a 45-year-old woman with type II diabetes, you ask her to collect her urine over 24 hours. She collects 3600 ml of urine in that period. The clinical laboratory returns the following results after analyzing the patient’s urine and plasma samples: plasma creatinine = 4 mg/dL, urine creatinine = 32 mg/dL, plasma potassium = 5 mmol/L, and urine potassium = 10 mmol/L.
What is the net renal tubular reabsorption rate of potassium in this patient?
TLS Online TPP Program

#Question id: 14079

#Unit 1. Molecules and their Interaction Relevant to Biology

Which DNA is favored in many solutions that are relatively devoid of water with the base pair per turn of
A. B DNA
B. A DNA
C. Z DNA
D. 10 bp per turn
E. 11 bp per turn
F. 12 bp per turn
Which of the following combination is correct?
TLS Online TPP Program

#Question id: 1387

#Unit 4. Cell Communication and Cell Signaling

The ability of a population of fibroblasts to migrate along the surface of a tissue culture dish depends on adhesion between the cell surface and the extracellular matrix molecules coating the dish. The dish is coated with laminin, and the only cell-surface protein capable of binding laminin is a cell-adhesion protein called an integrin. Integrins are integral plasma-membrane proteins that function as heterodimers. Under these conditions the rate at which a fibroblast can migrate along the laminin coated culture dish is proportional to the strength of adhesion between the cell and the laminin substrate. The table below lists the rate of cell migration observed for fibroblasts genetically engineered to generate the indicated phenotypes. Microinjection into the cytoplasm of a wild. type cell of a solution of a synthetic peptide possessing the same sequence as the integrin beta subunit cytoplasmic domain would be expected to yield an average fibroblast-cell migration rat

Fibroblast Phenotype

Level of Integrin Heterodimer at the Cell Surface (percent of wild type)

Rate of Cell Migration (pm/min) 

1. Wild type

100

2

2. Overexpression of the wild-type integrin alpha subunit

104

2

3. Overexpression of an integrin beta subunit lacking the cytoplasmic domain

96

0.6

4. Overexpression of the soluble cytoplasmic domain of an integrin beta subunit

98

0.6

5. Absence of the integrin alpha subunit

Less than 1

0.05

TLS Online TPP Program

#Question id: 4321

#Unit 3. Fundamental Processes

A genetic test to detect predisposition to cancer would likely examine the APC gene for involvement in which type(s) of cancer?
TLS Online TPP Program

#Question id: 4922

#Unit 8. Inheritance Biology

Following statement is correct for Genetic maternal effect. 

A- Characteristics are determined by autosomal genes

B- Inherited according to Mendel’s principles

C- Phenotype of offspring determine by protein factor that is inherited via egg cytoplasm