primary disruptions could be signaling the plant that a change in environmental conditions has occurred and that it’s time to respond by altering existing pathways or by activating stress-response pathways. At least five different types of stress-sensing mechanisms can be distinguished:

COLUMN I	COLUMN II
A) Physical sensing	i) usually results from the detection of by-products that accumulate in cells due to the uncoupling of enzymatic or electron transfer reactions, such as the accumulation of ROS during stress caused by too much light.
B) Biophysical sensing	ii) often involves the presence of specialized proteins that have evolved to sense a particular stress; for example, calcium channels that can sense changes in temperature and alter Ca2+ homeostasis.
C) Metabolic sensing	iii) refers to modifications of DNA or RNA structure that do not alter genetic sequences, such as the changes in chromatin that occur during temperature stress.
D) Biochemical sensing	iv) refers to the mechanical effects of stress on the plant or cell structure, for example, the contraction of the plasma membrane from the cell wall during drought stress.
E) Epigenetic sensing	v) might involve changes in protein structure or enzymatic activity, such as the inhibition of different enzymes during heat stress.

 

  

Match the correct sequence sensing mechanism during in stress;

#Question id: 1238

#Unit 4. Cell Communication and Cell Signaling

Which of the following can lead to loss-of-heterozygosity in a tumor-suppressor gene?

a. deletion of the normal copy                       

b. non dysjunction during mitosis

c. somatic mutation of the normal copy

d. mitotic recombination between a wild-type and mutant allele

#Question id: 1237

#Unit 4. Cell Communication and Cell Signaling

Arrange the following events in the proper order in which they occur during transduction of the Notch/Delta signaling pathway:

a. cleavage of Notch by TACE                                  

b. binding of Delta to Notch

c. translocation of Notch segment to the nucleus      

d. interaction of Notch with transcription factors     

e. cleavage of Notch by Presenilin 1  

#Question id: 1236

#Unit 4. Cell Communication and Cell Signaling

Arrange the following events in the proper order in which they occur during transduction of the TNF-α signal

a. phosphorylation of I-κB                 

b. binding of E3 ubiquitin ligase to I-κB       

c. polyubiquitination of I-κB             

d. nuclear localization of NF-κB       

e. activation of TAK1 kinase

#Question id: 1235

#Unit 4. Cell Communication and Cell Signaling

Arrange the following events in the proper order in which they occur during transduction of the EGF signal:

a. transphosphorylation of the EGF receptor

b. dissociation of GDP from Ras                   

c. dissociation of Ras from Sos         

d. binding of GRB2 to the EGF receptor      

e. binding of GTP to Ras  

#Question id: 1234

#Unit 4. Cell Communication and Cell Signaling

Which of the following mutations would likely have a similar cancer-promoting effect as the RasD mutation?

a. mutation in Grb2 so that it cannot bind Sos

b. mutation in Sos so that it binds Ras independent of Grb2

c. mutation in GAP so that it cannot bind Ras

d. mutation in EGF receptor so that it binds GRB2 independent of EGF

#Question id: 1233

#Unit 4. Cell Communication and Cell Signaling

Transphosphorylation (cross-phosphorylation) of receptor tyrosine kinases

a. inhibits catalytic activity.

b. promotes transphosphorylation of additional tyrosine residues.

c. triggers release of the ligand.

d. generates binding sites for signaling molecules.