#Question id: 1518
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.
A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.
B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.
C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.
D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.
Which of the following statements are incorrect?
#Question id: 1263
#Unit 4. Cell Communication and Cell Signaling
The major classes of CAMs include
a. cadherins. b. fibronectin. c. Ig-superfamily CAMs. d. P-selectins.
#Question id: 1264
#Unit 4. Cell Communication and Cell Signaling
Desmosomes
#Question id: 1265
#Unit 4. Cell Communication and Cell Signaling
An example of an integrin containing cell junction is
#Question id: 1266
#Unit 4. Cell Communication and Cell Signaling
Integrins
#Question id: 1267
#Unit 4. Cell Communication and Cell Signaling
Multiple integrin forms arise from