A man has three bags. There are 4 marbles of different colours in first bag, 5 marbles of different colours in second bag and 3 marbles of different colours in third bag. If two colours are such which are only in first and second bag and one colour is such which is in all the three bags, how many different colours are in all the three bags?

#Question id: 4115

#Unit 3. Fundamental Processes

The possible type of splicing outcome of given gene construct will be

#Question id: 4114

#Unit 3. Fundamental Processes

Splice-site recognition is prone to two kinds of errors. First, splice sites can be skipped, with components bound at, for example, a given 5’ splice site pairing with those at a 3’ site beyond the correct one. Ways in which the accuracy of splice-site selection can be enhanced are as

A. The factors that recognize that site are transferred from the polymerase carboxy-terminal “tail” onto the RNA. Once in place, the 5’ splice site components are poised to interact with those other factors that bind to the next 3’ splice site to be synthesized.

B. SR (serine–arginine-rich) proteins bind to sequences called exonic splicing enhancers (ESEs) within the exons. SR proteins bound to these sites recruit the splicing machinery to the nearby splice sites to ensure correct splicing

C. By recruiting splicing factors to each side of a given exon, this process encourages the so-called “exon definition, contribute to correct splicing

D. Alternative splicing is intentional missplicing mechanism

Which of the following is INCORRECT?

#Question id: 4113

#Unit 3. Fundamental Processes

Match the transcriptional machinery with their respective RNA Polymerase

#Question id: 4112

#Unit 3. Fundamental Processes

Which of the following is the structure of the nucleotide at the branch site of a spliced intron?

#Question id: 4111

#Unit 3. Fundamental Processes

Which of the following is NOT characteristic of a eukaryotic enhancer element?

#Question id: 4110

#Unit 3. Fundamental Processes

Tay-Sachs disease belongs to the family of lysosomal storage diseases; it is an autosomal recessive neurodegenerative disorder caused by deficiency of the lysosomal enzyme hexosaminidase. The inability to degrade sphingolipids results in the deposition of these lipids in the cells that causes severe mental retardation and death in childhood. The most common mutation in Tay-Sachs disease patients is a 4-base pair insertion in exon 11 of the 14 exons of the hexosaminidase gene. What could be the most likely consequence of this mutation?