Which of the following is correct about the native state of a protein

a. is unaffected by changes in temperature and pH.

b. corresponds to the highest Gibbs free energy state.

c. is determined by its primary amino acid sequence.

d. corresponds to the lowest entropic state.

#Question id: 1518

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.

A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.

B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.

C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.

D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.

Which of the following statements are incorrect?

#Question id: 1263

#Unit 4. Cell Communication and Cell Signaling

The major classes of CAMs include

a. cadherins.    b. fibronectin.    c. Ig-superfamily CAMs.      d. P-selectins.

#Question id: 1264

#Unit 4. Cell Communication and Cell Signaling

 Desmosomes

#Question id: 1265

#Unit 4. Cell Communication and Cell Signaling

An example of an integrin containing cell junction is

#Question id: 1266

#Unit 4. Cell Communication and Cell Signaling

Integrins

#Question id: 1267

#Unit 4. Cell Communication and Cell Signaling

Multiple integrin forms arise from