Practice Questions

  1. Home
  2. Free Resources
  3. Practice Questions
  4. 54875
TLS Online TPP Program

#Question id: 887

Polypeptides fold rapidly by a stepwise process, how does the polypeptide chain arrive at its native conformation?

#Unit 1. Molecules and their Interaction Relevant to Biology

  1. proteins appear to fold in a hierarchical manner, with small local elements of structure forming and then to yield larger elements, which coalesce with other such elements to form yet larger elements and converted into its native conformation

  2. A protein-folding pathway has been highly successful in predicting the three-dimensional structure of small proteins from their amino acid sequence atleast 156 amino acid residue that have acquired their final structure

  3. Vander waal interaction play a significant role throughout the process, as the aggregation of nonpolar amino acid side chains provides an entropic stabilization to intermediates and, eventually, to the final folded structure

  4. The native conformation of the protein folding by stepwise manner such as unfolded→transition state→molten globule→folded conformation by decreasing the free energy

More Questions
TLS Online TPP Program

#Question id: 15303

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by
a.  Loss of both alleles of NF1
b.  Mutation in RAS GAP-type protein
c.  A single mutant NF1 allele
d.  Mutation in SRC protein
TLS Online TPP Program

#Question id: 1538

#Unit 4. Cell Communication and Cell Signaling

Many aspects of the biology of stem cells, including maintenance of pluripotency, self-renewal, and differentiation, are controlled by the phenomenon of RNA interference involving a variety of small molecules of RNA.

Match the following miRNA (Column I) with their target gene (Column II).

Column I

Column II

a. Let-7 miRNA

i. Bcl-2

b. miR-16

ii. PTEN phosphatase

c. miR-125a and miR-125b

iii. Myc

d. miR-21

iv. LIN28

TLS Online TPP Program

#Question id: 1537

#Unit 4. Cell Communication and Cell Signaling

Transformation of mature cells may also occur due to aberrant expression of stemness genes, resulting in cell clones with a dedifferentiated phenotype and self-renewing capacity resembling stem cells. Recent experimental evidence supporting this proposal has been provided with the induction of adult somatic cells into pluripotent stem (iPS) cells through ectopic expression of four genes encoding the pluripotency factors Oct4 and Sox2, the transcription factor Klf4, and the oncoprotein c-Myc in mouse or human fibroblasts. However, along with pluripotency comes the capability of generating teratomas. On the basis of the above information which of the following outcome is most appropriate?
TLS Online TPP Program

#Question id: 1536

#Unit 4. Cell Communication and Cell Signaling

Use the following figure to answer the question. According to figure, which of the following statement is incorrect?
TLS Online TPP Program

#Question id: 1535

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to cancer stem cell (CSCs).

a. A representative subpopulation of cancer cells with peculiar molecular aspects that resemble some of those typical of normal stem cells.

b. These cells are capable of replenishing the repertoire of identical cancer cells.

c. These cells cannot create heterogeneous progeny that differentiate into more mature cells.

d. These cells show extraordinary proliferative potential.

e. These cells show excessive programmed cell death.

Which of the following combination is correct?
TLS Online TPP Program

#Question id: 1534

#Unit 4. Cell Communication and Cell Signaling

Cadherin proteins help animal cells stick (adhere) to each other. Choose which statement about cadherin in cancer cells that are metastasizing (spreading) throughout a patient's body is most likely correct.