Practice Questions

TLS Online TPP Program

#Question id: 879

Correct approaches to protein structure prediction-:

i. Homology modeling

a) Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure.

ii. Structural genomics

b) which seeks to determine the X-ray structures of all representative domains, is aimed at expanding this predictive technique. The identification of structural homology is likely to provide clues as to a protein’s function even with imperfect structure prediction.

iii. Threading

c) Is a computational technique that attempts to determine the unknown structure of a protein by ascertaining whether it is consistent with a known protein structure. It does so by placing the unknown protein’s residues along the backbone of a known protein structure and then determining whether the amino acid side chains of the unknown protein are stable in that arrangement

iv. Ab initio

d) Aligns the sequence of interest with the sequence of a homologous protein or domain of known structure—compensating for amino acid substitutions, insertions, and deletions—through modeling and energy minimization calculations.

#Unit 1. Molecules and their Interaction Relevant to Biology

i-d, ii-b, iii-c, iv-a
i-b, ii-d, iii-c, iv-a
i-d, ii-b, iii-a, iv-c
i-a, ii-b, iii-c, iv-d

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#Question id: 5367

#Unit 8. Inheritance Biology

Following pedigree showing X link recessive disorder. Which of the following confirm a carrier female in a family?

TLS Online TPP Program

#Question id: 5366

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the child in generation III will show the trait.

TLS Online TPP Program

#Question id: 5365

#Unit 8. Inheritance Biology

The following pedigree shows the inheritance of a common phenotype controlled by an autosomal recessive allele. The probability of carriers in the population is 1/3. What is the probability that a child from parents III-3 and III-4 will show the phenotype?

TLS Online TPP Program

#Question id: 5364

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in families shown below: Based on the above limited information, which one of the following inheritance patterns of disorder was not shown in the family?

TLS Online TPP Program

#Question id: 5362

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the daughter in generation III will show the trait.

TLS Online TPP Program

#Question id: 5361

#Unit 8. Inheritance Biology

The pedigree shows the inheritance of a RFLP marker through three generations in a single family. A total of 8 alleles (numbered to the left of the blots) are present in the family. The RFLPs of each member of the family are placed directly below his (squares) or her (circles) symbol and RFLP numbers. In Above pedigree, which of the following are not children of second generation parent?

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i. Homology modeling	a) Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure.
ii. Structural genomics	b) which seeks to determine the X-ray structures of all representative domains, is aimed at expanding this predictive technique. The identification of structural homology is likely to provide clues as to a protein’s function even with imperfect structure prediction.
iii. Threading	c) Is a computational technique that attempts to determine the unknown structure of a protein by ascertaining whether it is consistent with a known protein structure. It does so by placing the unknown protein’s residues along the backbone of a known protein structure and then determining whether the amino acid side chains of the unknown protein are stable in that arrangement
iv. Ab initio	d) Aligns the sequence of interest with the sequence of a homologous protein or domain of known structure—compensating for amino acid substitutions, insertions, and deletions—through modeling and energy minimization calculations.