TLS Online TPP Program

#Question id: 12835


Following statements are regarding to the surveillance mechanism. Which of the following statement is incorrect?

#Unit 2. Cellular Organization
  1. DNA damage leads to the activation of p21, a transcription factor that induces the expression of the gene encoding the CDK inhibitor p53.
  2. When the DNA damage occurs during S phase or in G2, Cdc25C inhibition by Chk1/2 results in the inhibition of mitotic CDKs and hence arrest in G2.
  3. Cells sense DNA replication stress that results in stalling or slowing of replication forks. Such stress triggers activation of the ATR-Chk1 checkpoint pathway and results in downregulation of S phase CDK activity and prevents the firing of late-replicating origins.
  4. ATM halts cell cycle progression by Chk2-mediated inhibition of Cdc25, thus preventing activation of CDKs. This inhibition can occur in G1 or G2.
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TLS Online TPP Program

#Question id: 12051

#Unit 7. System Physiology – Animal

Migrating motility complexes (MMC) occur about every 90 min between meals and are thought to be stimulated by the gastrointestinal hormone, motilin. An absence of MMCs causes an increase in which of the following?

TLS Online TPP Program

#Question id: 12050

#Unit 7. System Physiology – Animal

A clinical experiment is conducted in which one group of subjects is given 50 g of glucose intravenously and another group is given 50 g of glucose orally. Which of the following factors can explain why the oral glucose load is cleared from the blood at a faster rate compared to the intravenous glucose load? (CCK, cholecystokinin; GLIP, glucose-dependent insulinotropic peptide; VIP, vasoactive intestinal peptide)

TLS Online TPP Program

#Question id: 12049

#Unit 7. System Physiology – Animal

Which of the following hormones is released by the presence of fat and protein in the small intestine and has a major effect to decrease gastric emptying?

TLS Online TPP Program

#Question id: 12048

#Unit 7. System Physiology – Animal

A 10-year-old boy consumes a cheeseburger, fries, and chocolate shake. The meal stimulates the release of several gastrointestinal hormones. The presence of fat, carbohydrate, or protein in the duodenum stimulates the release of which of the following hormones from the duodenal mucosa?

TLS Online TPP Program

#Question id: 12047

#Unit 7. System Physiology – Animal

Biopsies are taken from the antral and duodenal mucosa of a 65-year-old woman. Which of the following hormones can be found in tissue homogenates from both locations?

TLS Online TPP Program

#Question id: 12046

#Unit 7. System Physiology – Animal

Which of the following ions has the highest concentration in saliva under basal conditions?