TLS Online TPP Program

#Question id: 12834


How Aurora B and the spindle assembly checkpoint pathway collaborate during every cell cycle to accurately attach every single pair of sister chromatids to the mitotic spindle in the correct, bioriented manner?

#Unit 2. Cellular Organization
  1. Aurora B phosphorylate microtubule-binding component of the kinetochore, the Ndc80 complex, leads to the generation of attached kinetochores, which are recognized by the spindle assembly checkpoint pathway.
  2. Aurora B phosphorylate microtubule-binding component of the kinetochore, the Ndc80 complex, leads to the generation of unattached kinetochores, which are recognized by the spindle assembly checkpoint pathway.
  3. Aurora B dephosphorylate microtubule-binding component of the kinetochore, the Ndc80 complex, leads to the generation of unattached kinetochores, which are recognized by the spindle assembly checkpoint pathway.
  4. Aurora B ubiquitinylates microtubule-binding component of the kinetochore, the Ndc80 complex, leads to the degradation of unattached kinetochores, which are recognized by the spindle assembly checkpoint pathway.
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TLS Online TPP Program

#Question id: 4119

#Unit 3. Fundamental Processes

Many eukaryotic genes contain a large number of exons. Correct splicing of such genes requires that neighboring exons be ligated to one another; if they are not, exons will be left out. One early proposal suggested that the splicing machinery bound to a splice site at one end of an intron and scanned through the intron to find the splice site at the other end. Such a scanning mechanism would guarantee that an exon was never skipped. This hypothesis was tested with one minigene with a duplicated 5ʹ splice site. Find diagram of the products you expect from minigene if the splicing machinery binds to a 5ʹ splice site and scans toward a 3ʹ splice site.

TLS Online TPP Program

#Question id: 927

#Unit 1. Molecules and their Interaction Relevant to Biology

In the disease sprue, vitamin B12 (cobalamin) is poorly absorbed in the intestine, resulting in B12 deficiency. If each of the following fatty acids were in the diet, for which one would the process of fatty acid oxidation be most affected in a patient with sprue?

TLS Online TPP Program

#Question id: 12559

#Unit 7. System Physiology – Animal

Which part of the renal tubule would have the lowest tubular fluid osmolarity in a patient who has complete lack of antidiuretic hormone due to “central” diabetes insipidus?

TLS Online TPP Program

#Question id: 3873

#Unit 3. Fundamental Processes

The excision (splicing) of many group I introns requires, in addition to the primary transcript RNA:

TLS Online TPP Program

#Question id: 3026

#Unit 2. Cellular Organization

Not present in all bacteria, this structure enables those that possess it to germinate after exposure to harsh conditions, such as boiling: