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TLS Online TPP Program

#Question id: 12185

Mitotic CDKs affect nuclear envelope components by specific mechanism. Which of the following statement is not related to this mechanism?

#Unit 2. Cellular Organization
  1. The CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate into subcomplexes during prophase. 
  2. Phosphorylation of integral membrane proteins of the inner nuclear membrane causes depolymerization of the lamin intermediate filaments.
  3. The weakening of the associations between the inner nuclear membrane proteins and the nuclear lamina and chromatin allows sheets of inner nuclear membrane to retract into the endoplasmic reticulum, which is continuous with the outer nuclear membrane.
  4. Mitotic CDKs induce the formation of the mitotic spindle. The function of the mitotic spindle is to segregate chromosomes so that the sister chromatids separate from each other and are moved to opposite poles of the cell.
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TLS Online TPP Program

#Question id: 12949

#Unit 7. System Physiology – Animal

At which renal tubular sites would the concentration of creatinine be expected to be highest in a normally hydrated person?
TLS Online TPP Program

#Question id: 12701

#Unit 7. System Physiology – Animal

In chronic respiratory acidosis with partial renal compensation, you would expect to find the following changes, compared to normal:___ urinary excretion of NH4+; ______ plasma HCO3− concentration; and _____ urine pH.
TLS Online TPP Program

#Question id: 12700

#Unit 7. System Physiology – Animal

A young man is found comatose, having taking an unknown number of sleeping pills an unknown time before. An arterial blood sample yields the following values: pH = 7.02, HCO3− = 14 mEq/L, and PCO2 = 68 mm Hg. This patient’s acid–base status is most accurately described as
TLS Online TPP Program

#Question id: 12699

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the free water clearance rate?
TLS Online TPP Program

#Question id: 12698

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the net potassium reabsorption rate?
TLS Online TPP Program

#Question id: 12697

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the approximate GFR?