#Question id: 895
#Unit 1. Molecules and their Interaction Relevant to Biology
Which of the following is van’t Hoff plot equation?
#Question id: 894
#Unit 1. Molecules and their Interaction Relevant to Biology
When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)
a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway
b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy
c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations
d) UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions
Which of the following statements would be incorrect?
#Question id: 893
#Unit 1. Molecules and their Interaction Relevant to Biology
Like E.coli eukaryotic cells also contain chaperonin, which of the following in eukaryotic chapronin is incorrect?
#Question id: 892
#Unit 1. Molecules and their Interaction Relevant to Biology
Assisted protein folding is mediated by a group of proteins known as chaperons, which of the following statements is incorrectly reperesents chaperon activity;
#Question id: 891
#Unit 1. Molecules and their Interaction Relevant to Biology
The folding pathways of some proteins require two enzymes that catalyze isomerization reactions such as,
a) Peptide prolyl isomerase (PPI) catalyzes the elimination of folding intermediates with inappropriate disulfide cross-links
b) Protein disulfide isomerase (PDI) enzyme that catalyzes the interchange, or shuffling, of disulfide bonds until the bonds of the native conformation are formed
c) Peptide prolyl cis-trans isomerase (PPI) catalyzes the interconversion of the cis and trans isomers of Proline residue peptide bonds
d) Peptide prolyl isomerase (PPI) can be a fast step in the folding of proteins that contain some Pro peptide bonds in the cis conformation
Which of the following combinations is correct about protein folding pathways?
#Question id: 890
#Unit 1. Molecules and their Interaction Relevant to Biology
Some of the misfolded protein or defective Protein causes disease as follows;
Disease Defective Protein
A) Parkinson’s disease i) Amyloid-β protein
B) Alzheimer’s disease ii) Superoxide dismutase
C) Huntington’s disease iii) Lysozyme
D) Lysozyme amyloidosis iv) α-Synuclein
E) Amyotrophic lateral sclerosis v) polyglutamate expansion
Match the correct disease with its misfolded proteins;