TLS Online TPP Program

#Question id: 2978


The most important regulatory control that restricts cyclins to the appropriate cell cycle stage is ubiquitin mediated, proteasome-dependent protein degradation. Which of the following statement is incorrect regarding to the degradation of protein?

#Unit 2. Cellular Organization
  1. SCF and APC/C are multisubunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin protein ligases which ensure that the cell cycle engine is driven forward and that cells cannot “go backward” in the cell cycle.

  2. SCF recognizes its substrates only when they are phosphorylated.

  3. The substrate specificity of active, dephosphorylated APC/C is determined in part by its association with one of two related substrate targeting factors called Cdc20 and Cdh1.

  4. The substrates of APC/C contain recognition motifs known as destruction box which is lysine rich.

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TLS Online TPP Program

#Question id: 10938

#Unit 7. System Physiology – Animal

A 45-year-old woman developed fatigue in July and had blood counts that were reported to be normal. She was hospitalized because of a very severe headache in December, and was found to have a blood pressure of 175/90. Her laboratory values were as follows: hemoglobin (8.3 g/dL), RBC count (2.2 × 10^6/μl), Hct (23%), MCV (89 fL), WBCs (5100/μl), platelets (262 × 10^3/μl), and reticulocyte count 0.8%. What is the diagnosis for this patient?

TLS Online TPP Program

#Question id: 10940

#Unit 7. System Physiology – Animal

Adhesion of white blood cells to the endothelium is

TLS Online TPP Program

#Question id: 10941

#Unit 7. System Physiology – Animal

In a normal healthy person, which of the following blood components has the shortest life span?

TLS Online TPP Program

#Question id: 10942

#Unit 7. System Physiology – Animal

A 45-year-old man presents to the emergency room with a 2-week history of diarrhea that has gotten progressively worse over the last several days. He has minimal urine output and is admitted to the hospital for dehydration. His stool specimen is positive for parasitic eggs. Which type of WBCs would have an elevated number?

TLS Online TPP Program

#Question id: 10943

#Unit 7. System Physiology – Animal

An 8-year-old male is frequently coming to the clinic for persistent skin infections that do not heal within a normal time frame. He had a normal recovery from the measles. Checking his antibodies following immunizations yielded normal antibody responses. A defect in which of the following cells would most like be the cause of the continual infections?

TLS Online TPP Program

#Question id: 10944

#Unit 7. System Physiology – Animal

Where does the transmigration of WBCs occur in response to infectious agents?