The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

TLS Online TPP Program

#Question id: 13122

#Unit 2. Cellular Organization

Choose the incorrect?

1- COPI vesicles transport proteins from the rough ER to the cis -Golgi; COPII vesicles transport proteins in the reverse s Direction.

2- The KDEL receptor binds more tightly to its ligand ar low pH, and it is thought that the receptor is able to bind KDEL peptides in the cis-Golgi but to release these peptides in the ER because the pH of the Golgi is slightly lower than that of the ER.

3- The KDEL sorting signal is recognized and bound by the KDEL receptor, a transmembrane protein found primarily on small transport vesicles shuttling between the ER and the cis -Golgi and on the cis-Golgi reticulum.

TLS Online TPP Program

#Question id: 13121

#Unit 2. Cellular Organization

--------- act as a nuclear export factor and directs the associated mRNP to the central channel of the NPC by transiently interacting with FG- nucleoporins.

TLS Online TPP Program

#Question id: 13120

#Unit 2. Cellular Organization

Match the correct one?

Target organelle	Location of sequence within protein	Removal of sequence	Nature of sequence
1- ER	i- N- terminal	a- yes	P- Core of 6-12 hydrophobic aa often preceded by one or more basic ammo acids (Arg, Lys)
2-Mtochrondria matrix	ii- N- terminal	b- yes	Q- Multiple different kinds;  rich in Lys and Arg residues
3-Chloroplast stroma	iii- N- terminal	c- no	R- Lys and arg one side and other side hydrophobic aa
4-Nucleus	iv-varies	d- yes	S- Generally rich in ser and thr, poor in glu and asp

TLS Online TPP Program

#Question id: 13119

#Unit 2. Cellular Organization

Ions, small metabolites, and globular proteins up to about ---------- can diffuse passively through the central aqueous region of the nuclear pore complex.

TLS Online TPP Program

#Question id: 2059

#Unit 2. Cellular Organization

For a protein to be an integral membrane protein, it would have to be:

TLS Online TPP Program

#Question id: 2060

#Unit 2. Cellular Organization

An animal cell lacking carbohydrates on the external surface of its plasma membrane would likely be impaired in which function?