The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

#Question id: 11496

#Unit 7. System Physiology – Animal

Forced rapid breathing results in alkalization of the blood which would lead to which of the following changes in neuronal activity?

#Question id: 11495

#Unit 7. System Physiology – Animal

In a neuron with a resting membrane potential of −65mV, the distribution of which ion across the neuronal membrane represents the greatest potential electromotive force (EMF)?

#Question id: 11226

#Unit 7. System Physiology – Animal

At the neuromuscular junction, the neurotransmitter acetylcholine (ACh) is degraded by acetylcholinesterase. If a neurophysiologist applies the naturally occurring acetylcholinesterase inhibitor, onchidal (produced by the mollusc Onchidella binneyi), to a synapse, what would you expect to happen?

#Question id: 11225

#Unit 7. System Physiology – Animal

What happens if twice as many inhibitory postsynaptic potentials (IPSPs) as excitatory postsynaptic potentials (EPSPs) arrive in close proximity at a postsynaptic neuron?

#Question id: 11224

#Unit 7. System Physiology – Animal

How could you increase the magnitude of excitatory postsynaptic potentials (EPSPs) generated at a synapse?

#Question id: 11223

#Unit 7. System Physiology – Animal

Of those listed, which event occurs first following a depolarizing stimulus applied to the presynaptic membrane of an axon terminal?