The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

#Question id: 19879

#Unit 13. Methods in Biology

#Question id: 10703

#Unit 10. Ecological Principles

Keystone predators can maintain species diversity in a community if they

#Question id: 11651

#Unit 10. Ecological Principles

Succession on a newly exposed site that was not previously occupied by soil and vegetation refers to

#Question id: 21130

#Unit 12. Applied Biology

#Question id: 7766

#Unit 5. Developmental Biology

The relationship between shortened telomeres and stem cell depletion has been seen in degenerative diseases such as mouse muscular dystrophy,

I) When____ is activated by damaged telomeres, DNA replication halts, and if the repair doesn’t work, apoptosis is initiated. If the cell is a stem cell or some other rapidly replicating cell, this will reduce the numbers of cells produced, and the lack of stem cells will produce an “aged” phenotype.

 II) When ____ is activated by damaged telomeres, DNA replication halts, repair do its work, apoptosis is inhibited. If the cell is a stem cell or some other rapidly replicating cell, this will increase the numbers of cells produced, and then these cells will produce an “aged” phenotype.

 Choose correct gene name with right statement