Following statements are regarding to the desensitization mechanism of GPCR.

A. Several residues in the cytosolic domain of the β-adrenergic receptor are phosphorylated by the enzyme rhodopsin kinase.

B. β-Arrestin binds to specific phosphorylated tyrosine residues in the C-terminal segment of G protein–coupled receptors (GPCRs).

C. Clathrin and AP2, two other proteins bound by β-arrestin, promote endocytosis of the receptor.

D. β-Arrestin also functions in transducing signals from activated receptors by binding to and activating several cytosolic protein kinases like Src activates the MAP kinase pathway, leading to phosphorylation of key transcription factor.

Which of the following combination is incorrect?

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#Question id: 5203

#Unit 11. Evolution and Behavior

The biggest problem with the shotgun technique is its tendency to underestimate the size of the genome. Which of the following might best account for this?

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#Question id: 12392

#Unit 6. System Physiology – Plant

 According to the acid growth hypothesis, the source of the hydrogen ions is the plasma membrane H+-ATPase, whose activity is thought to increase in response to

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#Question id: 369

#Unit 1. Molecules and their Interaction Relevant to Biology

Calculate the pH of a 2.0 L solution containing 10 mL of 5 M acetic acid and 10 mL of 1 M sodium acetate. (pKa = 4.76)

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#Question id: 12659

#Unit 7. System Physiology – Animal

 Which of the following would tend to decrease plasma potassium concentration by causing a shift of potassium from the extracellular fluid into the cells?

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#Question id: 4163

#Unit 3. Fundamental Processes

The net effect of all amino acid tRNA synthetases binding to a tRNA is to position the __ of tRNA in the active site.