Scaffolds for MAP kinase pathways are well documented in yeast, fly, and worm cells, but their presence in mammalian cells has been difficult to demonstrate. Perhaps the best documented scaffold protein in metazoans is Ksr (kinase suppressor of Ras).

A. Ksr functions as a molecular scaffold by binding several signaling components of the MAP kinase cascade, including both MEK and MAP kinase; and thus can enhance MAP kinase activation by regulating the efficiency of these interactions.

B. Ksr function as a protein kinase which constitutive activate RTK signalling pathway.

C. Ksr function as a receptor proteins which inhibits RTK signalling pathway.

D. Ksr function as a protein phosphatase which inhibits RTK signalling pathway.

Which of the following statement is correct about Ksr?

#Question id: 11031

#Unit 7. System Physiology – Animal

Atrial systole ________.

#Question id: 11030

#Unit 7. System Physiology – Animal

While jogging, a person has a stroke volume of 130 ml/beat and a heart rate of 120 beats per minute. If their resting stroke volume was 70 ml/beat and resting heart rate was 60 beats per minute, how did this person's cardiac output change?

#Question id: 11029

#Unit 7. System Physiology – Animal

Damage to the sinoatrial node in humans would ________.

#Question id: 11028

#Unit 7. System Physiology – Animal

A patient with a heart rate of 70 beats per minute and a stroke volume of 70 mL/beat will have a cardiac output of ________.

#Question id: 11026

#Unit 7. System Physiology – Animal

Listed below are the hydrostatic and oncotic pressures and filtration rate across a muscle capillary wall:

Capillary hydrostatic pressure (Pc) = 25 mm Hg

Plasma colloid osmotic pressure (Πp) = 25 mm Hg

Interstitial colloid osmotic pressure (ΠI) = 10 mm Hg

Interstitial hydrostatic pressure (PI) = −5 mm Hg

Capillary filtration rate = 150 ml/min

What is the capillary filtration coefficient?

#Question id: 11025

#Unit 7. System Physiology – Animal

Listed below are the hydrostatic and oncotic pressures within a microcirculatory bed:

Plasma colloid osmotic pressure = 25 mm Hg

Capillary hydrostatic pressure = 25 mm Hg

Venous hydrostatic pressure = 5 mm Hg

Arterial pressure = 80 mm Hg

Interstitial fluid hydrostatic pressure = −5 mm Hg

Interstitial colloid osmotic pressure = 10 mm Hg

Capillary filtration coefficient = 10 ml/min/mm Hg

What is the rate of net fluid movement across the capillary wall?