Following statements are regarding to the mechanism of action of cholera toxin.

A. cholera toxin is a homodimeric protein, target G proteins, interfering with normal signaling in host cells.

B. cholera toxin associates with a small G protein, known as ARF6.

C. association with ARF6 activates cholera toxin, which catalyzes the transfer of ADP-ribose from NAD+ to the critical Arg residue in the P loop of the alpha subunit of Gs.

D. ADP-ribosylation blocks the GEF activity of Gs and thereby renders Gs permanently inactive.

E. This results in continuous activation of the adenylyl cyclase of intestinal epithelial cells, chronically high cAMP, and active PKA dephosphorylates the CFTR Cl- channel and a sodium-proton exchanger in the intestinal epithelial cells.

Which of the following combination is correct?

TLS Online TPP Program

#Question id: 27479

#Unit 1. Molecules and their Interaction Relevant to Biology

For monosaccharides having  two or more asymmetric carbons, their L or D con configuration can be decided by using

TLS Online TPP Program

#Question id: 27478

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following are the minimum essential criteria for the chirality of Aldoses and ketoses

TLS Online TPP Program

#Question id: 27424

#Unit 1. Molecules and their Interaction Relevant to Biology

Conversion of antigen are possible with the help of enzyme then O  A antigen , O B antigen these conversion are catalysed by enzyme a and b which are

TLS Online TPP Program

#Question id: 27423

#Unit 1. Molecules and their Interaction Relevant to Biology

Cholesterol Poor region are maintained in the

TLS Online TPP Program

#Question id: 27422

#Unit 1. Molecules and their Interaction Relevant to Biology

There are two extreme states of bilayer lipids choose which of the following is correct  

1.In the liquid- ordered (Lo) state, polar head groups are non uniformly arrayed at the surface, and the acyl chains are nearly motionless and packed with irregular

2.in the liquid- ordered (Lo) state, polar head groups are uniformly arrayed at the surface, and the acyl chains are nearly motionless and packed with regular

3.In the liquid-disordered (Ld) state acyl chains undergo much thermal motion and have regular organization.

4.In the liquid-disordered (Ld) state, acyl chains undergo much thermal motion and have no regular organization.

TLS Online TPP Program

#Question id: 27421

#Unit 1. Molecules and their Interaction Relevant to Biology

Highest concentration of cholesterol are found in