Following statements are regarding to the wnt signalling.

A. Wnt proteins interact with several cell-surface proteins and activate multiple downstream signal transduction pathways. The principal signaling receptor for Wnt proteins is Frizzled (Fz), which contains seven transmembrane α helices.

B. The palmitate attached to the Wnt protein binds to a specific site on the Fz intracellular domain and stabilizes the Wnt-Fz complex.

C. “canonical” Wnt signaling pathway uses a second transmembrane protein, LRP, that associates with Frizzled in a Wnt signal– dependent manner.

D. In the resting state, two kinases in the complex, casein kinase 1 (CK1) and GSK3, sequentially phosphorylate β-catenin on multiple tyrosine residues.

Which of the following statements are correct?

#Question id: 895

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is van’t Hoff plot equation?

#Question id: 894

#Unit 1. Molecules and their Interaction Relevant to Biology

When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

#Question id: 893

#Unit 1. Molecules and their Interaction Relevant to Biology

Like E.coli eukaryotic cells also contain chaperonin, which of the following in eukaryotic chapronin is incorrect?

#Question id: 892

#Unit 1. Molecules and their Interaction Relevant to Biology

Assisted protein folding is mediated by a group of proteins known as chaperons, which of the following statements is incorrectly reperesents chaperon activity;

#Question id: 891

#Unit 1. Molecules and their Interaction Relevant to Biology

The folding pathways of some proteins require two enzymes that catalyze isomerization reactions such as,

a) Peptide prolyl isomerase (PPI)  catalyzes the elimination of folding intermediates with inappropriate disulfide cross-links

b) Protein disulfide isomerase (PDI) enzyme that catalyzes the interchange, or shuffling, of disulfide bonds until the bonds of the native conformation are formed

c) Peptide prolyl cis-trans isomerase (PPI) catalyzes the interconversion of the cis and trans isomers of Proline residue peptide bonds

d) Peptide prolyl isomerase (PPI) can be a fast step in the folding of proteins that contain some Pro peptide bonds in the cis conformation

Which of the following combinations is correct about protein folding pathways?

#Question id: 890

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the misfolded protein or defective Protein causes disease as follows;

               Disease                                             Defective Protein

A)  Parkinson’s disease                                  i) Amyloid-β protein

B)  Alzheimer’s disease                                  ii) Superoxide dismutase

C) Huntington’s disease                                iii) Lysozyme

D) Lysozyme amyloidosis                             iv) α-Synuclein

E) Amyotrophic lateral sclerosis                   v) polyglutamate expansion

Match the correct disease with its misfolded proteins;