Following statements are regarding to the wnt signalling.

A. Wnt proteins interact with several cell-surface proteins and activate multiple downstream signal transduction pathways. The principal signaling receptor for Wnt proteins is Frizzled (Fz), which contains seven transmembrane α helices.

B. The palmitate attached to the Wnt protein binds to a specific site on the Fz intracellular domain and stabilizes the Wnt-Fz complex.

C. “canonical” Wnt signaling pathway uses a second transmembrane protein, LRP, that associates with Frizzled in a Wnt signal– dependent manner.

D. In the resting state, two kinases in the complex, casein kinase 1 (CK1) and GSK3, sequentially phosphorylate β-catenin on multiple tyrosine residues.

Which of the following statements are correct?

#Question id: 5364

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in families shown below: Based on the above limited information, which one of the following inheritance patterns of disorder was not shown in the family?

#Question id: 5362

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the daughter in generation III will show the trait.

#Question id: 5361

#Unit 8. Inheritance Biology

The pedigree shows the inheritance of a RFLP marker through three generations in a single family. A total of 8 alleles (numbered to the left of the blots) are present in the family. The RFLPs of each member of the family are placed directly below his (squares) or her (circles) symbol and RFLP numbers. In Above pedigree, which of the following are not children of second generation parent?

#Question id: 5360

#Unit 8. Inheritance Biology

Following some different genetic disorder traces in families. 

 Which of the following possible mode of inheritance in the Family A, B, C and D respectively

#Question id: 5359

#Unit 8. Inheritance Biology

Which of the following mode of inheritance and selected individuals must be carrier showing in above pedigree?

#Question id: 5358

#Unit 8. Inheritance Biology

In the following pedigree, individuals with shaded show presence of a recessive autosomal trait. If all individual is coming from outside the family is homozygous for normal. The calculated risk of occurrence of this trait for (?) individual is