Following statements are regarding to the phosphoinositide signaling pathway.

A. Many RTKs and cytokine receptors can initiate the IP3/ DAG signaling pathway by activating phospholipase Cβ (PLCβ), a different PLC isoform.

B. Activated RTKs and cytokine receptors also can initiate another phosphoinositide pathway by binding a PI-3 kinase, thereby allowing the enzyme access to its membrane-bound phosphoinositide substrates, which then become phosphorylated at the 3 position.

C. Protein kinase B (PKB) becomes partially activated by binding to PI 3-phosphates with its PH domain.

D. Full activation of PKB requires phosphorylation by the kinase PDK1, which is also recruited to the membrane by binding to PI 3-kinase, and by a second kinase, PDK2.

Which of the following combination is incorrect?

#Question id: 23753

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 23752

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 23751

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 743

#Unit 1. Molecules and their Interaction Relevant to Biology

Glycophorin, an integral membrane protein, has a single transmembrane alpha helix. Which of the following idealized hydropathy plots most likely represents the transmembrane nature of glycophorin?

#Question id: 742

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

#Question id: 741

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of following statements are INCORRECT about secondary structure of proteins

A. Long block of Glu residues segment of the chain will not form an alpha helix at pH 7.0 but it ll take helical confirmation below its pKR value

B. Long block of Lys residues segment of the chain will not form an alpha helix at pH 7.0 but it ll take helical confirmation above its pKR value

C. Long block of Ala residues segment of the chain will not form an alpha helix at pH 7.0 but it ll take helical confirmation below its pKR value

D. Histidine side chain remain uncharged over pH range 3-6