Following statements are regarding to the phosphoinositide signaling pathway.

A. Many RTKs and cytokine receptors can initiate the IP3/ DAG signaling pathway by activating phospholipase Cβ (PLCβ), a different PLC isoform.

B. Activated RTKs and cytokine receptors also can initiate another phosphoinositide pathway by binding a PI-3 kinase, thereby allowing the enzyme access to its membrane-bound phosphoinositide substrates, which then become phosphorylated at the 3 position.

C. Protein kinase B (PKB) becomes partially activated by binding to PI 3-phosphates with its PH domain.

D. Full activation of PKB requires phosphorylation by the kinase PDK1, which is also recruited to the membrane by binding to PI 3-kinase, and by a second kinase, PDK2.

Which of the following combination is incorrect?

TLS Online TPP Program

#Question id: 24212

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the correct statement

a. Hexokinases IV remains sequesters in the nucleus in case of high F-6-P and high ATP

b. Hexokinases IV remains sequesters in the cytoplasm in case of high F-6-P and high ATP

c. Hexokinase requires Mg+2 for its activity, because the true substrate of the enzyme is not ATP4- but the MgATP2- complex.

d. Hexokinase requires Mg+2 for its activity, because the true substrate of the enzyme is MgATP4- but not the MgATP2- complex.

TLS Online TPP Program

#Question id: 24211

#Unit 1. Molecules and their Interaction Relevant to Biology

Plot of hexokinase IV (Glucokinase) is different While Hexokinases I, II, and III have similar kinetic properties. So, in given graph which of the following represents hexokinase IV and Hexokinases I, II, and III

a. i is representing Hexokinases IV

b. ii is representing Hexokinases I, II, and III

c. i is representing Hexokinases I, II, and III

d. ii is representing Hexokinases IV

Choose the correct option

TLS Online TPP Program

#Question id: 24210

#Unit 1. Molecules and their Interaction Relevant to Biology

The human genome encodes four different hexokinases (I to IV), all of which catalyze the same reaction. If Two or more enzymes that catalyze the same reaction but are encoded by different genes are called to be

TLS Online TPP Program

#Question id: 24209

#Unit 1. Molecules and their Interaction Relevant to Biology

Two enzyme having same reaction mechanism using same cofactor such as PDC and KDC

TLS Online TPP Program

#Question id: 24208

#Unit 1. Molecules and their Interaction Relevant to Biology

What is the true substrate for hexokinase

TLS Online TPP Program

#Question id: 14146

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

A. Cyanide 1. Inhibit cytochrome oxidase

B. Piericidin A 2. Prevent electron transfer from Fe-S center to ubiquinone

C. Antimycin A 3. Blocks electron transfer from cytochrome b to cytochrome c1

D. Valinomycin 4. K+ ionophore