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TLS Online TPP Program

#Question id: 1244

Which type of experimental evidence shows that the intrinsic GTPase activity of the Gα subunit is important for terminating effector activation?

#Unit 4. Cell Communication and Cell Signaling

  1. A nonhydrolyzable GTP analog that can bind to the Gα subunit but cannot be hydrolyzed by the intrinsic GTPase, thereby activating the effector protein longer upon ligand-induced activation of the receptor. 

  2. A nonhydrolyzable GTP analog causes displacement of GDP with the modified GTP resulting in continuous activation of the receptor because the bound GTP analog cannot be hydrolyzed to GDP.

  3. A dominant active (constant activity) GEF causes stimulation of the effector protein for longer upon ligand-induced activation of the receptor.

  4. A dominant negative (no activity) GEF causes stimulation of the effector protein for longer upon ligand-induced activation of the receptor.

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TLS Online TPP Program

#Question id: 15443

#Unit 4. Cell Communication and Cell Signaling

The caspases have which amino acid residues in their catalytic site and what is the cleavage site of these effector proteases;
TLS Online TPP Program

#Question id: 15442

#Unit 4. Cell Communication and Cell Signaling

XIAP, one member of a family of inhibitor of apoptosis proteins (IAPs), provides another way to restrain both initiator and effector caspases; Find out the INCORRECT statements about this inhibitor-
TLS Online TPP Program

#Question id: 15441

#Unit 4. Cell Communication and Cell Signaling

In hermaphrodites, expression of the egl-1 gene in the neurons is repressed by the transcription factor, and deletion of that causes these neurons to undergo apoptosis;
TLS Online TPP Program

#Question id: 15369

#Unit 4. Cell Communication and Cell Signaling

Changes in DNA methylation, as well as changes in the activity of histone-modifying enzymes or chromatin-remodeling complexes, are major drivers of tumorigenesis,
a. Hypermethylation of CpG dinucleotides of TSG gene causes cancer.
b. Hypomethylation of CpG dinucleotides of proto-oncogenes causes cancer.
c. SWI/SNF plays a role in repressing the expression of E2F genes.
d. Gain of SWI/SNF function, just like loss of Rb function.
Which of the statements are INCORRECT;
TLS Online TPP Program

#Question id: 15368

#Unit 4. Cell Communication and Cell Signaling

Recent evidence from humans and mice has strongly implicated the SNF5 gene in cancer. The SNF5 protein is a core member of the;
TLS Online TPP Program

#Question id: 15367

#Unit 4. Cell Communication and Cell Signaling

Genes whose protein products stimulate apoptosis behave as tumor suppressors, An example is the PTEN gene, The phosphatase encoded by this gene dephosphorylates phosphatidylinositol 3,4,5-trisphosphate, a secondary messenger that functions in activation of AKT, cells lacking PTEN phosphatase shows; EXCEPT