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TLS Online TPP Program
#Question id: 1084
#Unit 4. Cell Communication and Cell Signaling
Which observation suggested to Sutherland the involvement of a second messenger in epinephrine's effect on liver cells?
TLS Online TPP Program
#Question id: 5365
#Unit 8. Inheritance Biology
The following pedigree shows the inheritance of a common phenotype controlled by an autosomal recessive allele. The probability of carriers in the population is 1/3. What is the probability that a child from parents III-3 and III-4 will show the phenotype?
TLS Online TPP Program
#Question id: 23545
#General Aptitude
Deemed Universities declared by UGC under Section 3 of the UGC Act 1956, are not permitted to
TLS Online TPP Program
#Question id: 5338
#Unit 8. Inheritance Biology
Which one of the following is not true for a disease inherited as a sex-linked dominant in humans?
TLS Online TPP Program
#Question id: 14686
#Unit 4. Cell Communication and Cell Signaling
This member of the AKAP family, designated mAKAP, anchors both PDE and the regulatory subunit of PKA to the nuclear membrane, maintaining them in a negative feedback loop that provides close local control of the ATP level and PKA activity.
B- The basal level of PDE activity in the presence of hormone (resting state) keeps cAMP levels below those necessary for PKA activation.
C- Activation of β-adrenergic receptors causes an increase in cAMP to a level in excess of that which can be degraded by PDE.
D- The resulting binding of cAMP to the R subunits of PKA releases the active catalytic (C) subunits into the cytosol. Some C subunits enter the nucleus, where they phosphorylate and thus activate certain transcription factors . Other C subunits phosphorylate PDE, stimulating its catalytic activity.
E- Active PDE hydrolyzes cAMP, thereby driving cAMP levels back to basal levels and causing re-formation of the inactive PKA C-R complex. Subsequent de-phosphorylation of PDE returns the complex to the resting state.