For pro-proliferation signaling pathways to cause uncontrolled proliferation, as is seen in cancer, this p53 up-regulation must not occur, It is therefore not surprising that p53 is inactive in most human tumors through loss of p53 function itself, down-regulation of positive regulators (PR) of p53 or up-regulation of negative regulators (NR) of p53, these regulators are accordingly

TLS Online TPP Program

#Question id: 26465

#Unit 3. Fundamental Processes

Breaking and remaking bonds in the process of the nucleotide addition cycle and undergoing translocation by a 

a. Necleosome paradox 

b. Parrondo’s paradox

c. Brownian ratchet 

d. C value paradox

TLS Online TPP Program

#Question id: 26464

#Unit 3. Fundamental Processes

Choose the correct statement During abortive Transcription 

a. Abortive synthesis takes before escaping the promoter (-10 to +2), entering the elongation phase 

b. Abortive synthesis produces and releases short RNA transcripts of 10 nucleotides 

c. The major phenomenon which is responsible is Brownian ratchet 

d. Three general models were associated is “Scrunching”

TLS Online TPP Program

#Question id: 16493

#Unit 3. Fundamental Processes

35S promoter sequences derived from cauliflower mosaic virus shows which type of expression.

TLS Online TPP Program

#Question id: 24498

#Unit 3. Fundamental Processes

SR proteins are involved in exon definition in which they interact with U1 and U2AF forming the commitment for

TLS Online TPP Program

#Question id: 24491

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence CCUUAACU

TLS Online TPP Program

#Question id: 24490

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence UACUAAC?