The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β ‐catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E‐Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

#Question id: 11104

#Unit 7. System Physiology – Animal

The serous membrane covering the surface of the lungs is called the:

#Question id: 2274

#Unit 2. Cellular Organization

Unlike those of prokaryotes, eukaryotic cell walls are composed of

#Question id: 10284

#Unit 6. System Physiology – Plant

Allosteric regulation of enzyme multisubunit or multiactive site shows cooperativity with the sigmoidal graph between substerate conc. v/s Activity,

a) Cell contain NADH, FADH2 and ATP, that inhibits the allosteric enzyme activity by lowering the affinity with its substate, graph shifts towards B from control

 b) A- shows low ATP, the Km for fructose 6-phosphate is relatively low, the affinity of the enzyme with its substate is relatively high

 c) Haemoglobin, Phosphofructokinase, Phosphate dehydrogenase complex, α-ketoglutarate dehydrogenase complex, these all enzymes shows characteristics of sigmoidal graph

 d) When ATP is high, Km for fructose 6-phosphate is greatly increased- this activity shown by B in the graph

 e) fructose 2,6-bisphosphate binds to its allosteric site on PFK-1, it increases the enzyme’s affinity for its substrate fructose 6-phosphate and reduces its affinity for the allosteric inhibitors ATP and citrate- shown in graph by A

 Which of the following  combination of the enzyme activity with its substate correctly shown;

#Question id: 9280

#Unit 6. System Physiology – Plant

Oxygen-Evolving Organisms Have two Photosystems that Operate in Series, explain by emerson that is the Photosystem I preferentially absorbs far-red light of wavelengths greater than 680 nm; photosystem II preferentially absorbs red light of 680 nm and is driven very poorly by far-red light; Another difference between the photosystems is that,

a.) Photosystem I produces a strong reductant, capable of reducing NADP+, and a weak oxidant

b.) Photosystem I produces a very strong oxidant, capable of oxidizing water, and a weaker reductant than the one produced by photosystem II

c.) Photosystem II produces a strong reductant, capable of reducing NADP+, and a weak oxidant

d.) Photosystem II produces a very strong oxidant, capable of oxidizing water, and a weaker reductant than the one produced by photosystem I

Which statements would be CORRECT?

#Question id: 11572

#Unit 7. System Physiology – Animal

When a person drinks alcohol, the rate of urination increases. Which of the following best accounts for the increase in urination above normal rates?