TLS Online TPP Program

#Question id: 1533


Why might using retroviral vectors for gene therapy increase the patient's risk of developing cancer?

#Unit 4. Cell Communication and Cell Signaling
  1. Retroviral vectors may introduce proteins from the virus.

  2. Retroviral vectors do not express the genes that were introduced into a patient's cells.

  3. Retroviral vectors do not integrate their recombinant DNA into the patient's genome.

  4. Retroviral vectors integrate recombinant DNA into the genome in ways that may misregulate the expression of genes at or near the site of integration.

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TLS Online TPP Program

#Question id: 641

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following does NOT describe a mechanism that cells use to regulate enzyme activities?

A. Cells control enzyme activity by phosphorylation and dephosphorylation.

B. Cells control enzyme activity by the binding of small molecules.

C. Cells control the rates of diffusion of substrates to enzymes.

D. Cells control the rates of enzyme degradation.

E. Cells control the rates of enzyme synthesis.

F. Cells control the targeting of enzymes to specific organelles. 

TLS Online TPP Program

#Question id: 640

#Unit 1. Molecules and their Interaction Relevant to Biology

The data in the table above were collected for an enzyme-catalyzed reaction. The Km for this enzyme is approximately

TLS Online TPP Program

#Question id: 639

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the coenzymes in column I enzymes to class of enzymes in column II

EnzymeReaction Type
A. Phosphofructokinase1. Redox reaction
B. Enolase2. Phosphoryl shift
C. Phosphoglycerate mutase3. Dehydration
D. Glyceraldehyde 3 Phosphate dehydrogenase4. Phosphoryl transfer

TLS Online TPP Program

#Question id: 638

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following class of enzymes with them

EnzymeClass of enzyme
A. Hexokinase1
B. Phosphoglucoisomerase2
C. Glyceraldehyde 3-phosphate dehydrogenase3
D. Phosphoglycerate mutase4
E. Enolase5
F. Aldolase

TLS Online TPP Program

#Question id: 637

#Unit 1. Molecules and their Interaction Relevant to Biology

Effect of temperature on enzymatic catalysis is analysed by the rate v of a chemical reaction varies with temperature according to the Arrhenius Equation which explains the sensitivity of enzyme reactions to temperature. A plot to determination of the activation energy Ea involves

TLS Online TPP Program

#Question id: 636

#Unit 1. Molecules and their Interaction Relevant to Biology

DNA polymerase contains a lysine residue that is important for binding to DNA. Mutations were found that converted this lysine to either glutamate, glycine, valine, or arginine. Which mutations would be predicted to be the most and least harmful to the ability of the enzyme to bind DNA?

Most

Least

(A)

Valine

Aspartate

(B)

Glycine

Arginine

(C)

Arginine

Glycine

(D)

Glutamate

Arginine