TLS Online TPP Program

#Question id: 1532


For a particular microarray assay (DNA chip), cDNA has been made from the mRNAs of a dozen patients' breast tumor biopsies. Which of the following types of evidence will researchers be looking for in order to determine if the cells are cancerous?

#Unit 4. Cell Communication and Cell Signaling
  1. a particular gene that is amplified in all or most of the patient samples

  2. a pattern of fluorescence that indicates which cells are over proliferating

  3. a pattern shared among some or all of the samples that indicates gene expression differing from control samples

  4. a group of cDNAs that match those in non-breast cancer control samples from the same population

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TLS Online TPP Program

#Question id: 5232

#Unit 11. Evolution and Behavior

Using molecular clock, it was estimated that two species X and Y must have diverged from their common ancestor about 5 x 10^6 years ago. If the rate of divergence per base pair is estimated to be 0.06 per million years, what is the proportion of base pairs that differ between the two species now?

TLS Online TPP Program

#Question id: 5225

#Unit 11. Evolution and Behavior

Homeotic genes contain a homeobox sequence that is highly conserved among very diverse species. The homeobox is the code for that domain of a protein that binds to DNA in a regulatory developmental process. Which of the following would you then expect?

TLS Online TPP Program

#Question id: 5221

#Unit 11. Evolution and Behavior

Unequal crossing over during Prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, known as hemoglobin Lepore, is known in the human population. Hemoglobin Lepore has a deleted set of amino acids. If it was caused by unequal crossing over, what would be an expected consequence?

TLS Online TPP Program

#Question id: 5220

#Unit 11. Evolution and Behavior

In comparing the genomes of humans and those of other higher primates, it is seen that humans have a large metacentric pair we call chromosome #2 among our 46 chromosomes, while the other primates of this group have 48 chromosomes and any pair like the human #2 pair is not present; instead the primate groups each have two pairs of midsize acrocentric chromosomes. What is the most likely explanation?

TLS Online TPP Program

#Question id: 5217

#Unit 11. Evolution and Behavior

Multigene families include two or more nearly identical genes or genes sharing nearly identical sequences. A classical example is the set of genes for globin molecules, including genes on human chromosomes 11 and 16. How might identical and obviously duplicated gene sequences have gotten from one chromosome to another?

TLS Online TPP Program

#Question id: 5212

#Unit 11. Evolution and Behavior

Barbara McClintock, famous for discovering that genes could move within genomes, had her meticulous work ignored for nearly 4 decades, but eventually won the Nobel Prize. Why was her work so distrusted?